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Embedding health security in fiscal policy can reduce economic losses and avert deaths during a pandemic.

Five critical reforms can bolster global health systems against pandemics, climate change, and emerging infectious disease threats.

Investments must focus on diverse vaccine platforms, capacity building, and collaborative networks.

Feasibility assessments, demand forecasting, and direct public investments in manufacturing facilities support sustainable vaccine manufacturing.

Building regional regulatory capabilities in Asia and the Pacific requires strong oversight and sustained commitment to strengthening vaccine regulatory systems.